123 Anti-BP180, Pruritus, and Thymus and Activation-Regulated Chemokines as Surrogate Markers for Disease Activity in Bullous Pemphigoid

Bullous pemphigoid disease activity index (BPDAI) is the standard indicator of in bullous (BP). However, examining patients’ whole body burdensome to both patient and health care workers subjected inter-examiner bias, hence need investigate other surrogate markers for BPDAI. The purpose study quantify correlate candidate BP namely visual analogue scale pruritus (VAS-pruritus), thymus activation-regulated chemokines (TARC), anti-BP180 (BPDAI). A total 29 cases were examined; clinical marker (BPDAI), conventional biomarkers (anti-BP180, TARC score) reported VAS-pruritus measured correlated throughout course disease. We calculated a statistical cross-correlation function (CCF) between two time-series variables BPDAI VAS-pruritus, TARC, anti-BP180. CCF ranges from -1 1, indicating that 1 means perfect positive negative correlation. change anti-BP180, 0.928, 0.972, 0.923 respectively, changes highly with aforementioned markers. therefore conclude antiBP-180, may be used as monitor activity.